The Miller Lab at Truman State University was established in 2015 and we have started many new projects over the years.
In general, the Miller group seeks to use molecular modeling tools to discover and design new potential small-molecule drugs targeting proteins known to cause major health conditions in humans. Initially, molecular docking and de novo design methods are used to generate and crudely test millions of small molecules against biological targets. Molecular dynamics simulations and end-state free energy calculations are utilized to further refine promising ligands. Currently, the Miller group works on projects related to COVID-19, Alzheimer’s disease, endometriosis, cancer, HIV, and mental health disorders.
Students who do research in Dr. Miller’s lab get to
- Experience the beginning of the drug design process in pharmaceuticals
- Gain an understanding of common biochemistry terms and techniques
- Learn the basics of unix, coding, and computational chemistry
- Present their results at local, regional, and/or national research conferences
Below are a list of projects in the lab
Current Projects
Retired Projects
Asphaltenes
Cisplatin
HER2
Lewy bodies