C-MYB

c-Myb Project

cMyb (light blue)  and the KIX domain (tan) with a ligand bound at the protein-protein interface
cMyb (light blue) and the KIX domain (tan) with a ligand bound at the protein-protein interface
c-Myb (red) and KIX (blue)
c-Myb (red) and KIX (blue)
Celestrol bound to KIX
Celestrol bound to KIX
Celestrol 2D structure
Celestrol 2D structure
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This is a pretty new, and relatively simple project that seeks to inhibit the c-myb protein which would stop a protein cascade involved in the proliferation of acute myeloid leukemia. The c-Myb protein serves as a transcription factor that then goes on to regulate the expression of other genes, and when there is a high level of the c-Myb protein it can help sustain the presence of the cancerous cells. The idea behind the project is to inhibit the active site of the c-myb protein between a lysine and glutamine residues using Celastrol as a scaffold for our drug candidates. We are working in conjunction with a clinical researcher at UChicago and will be reporting our results to them in time.

Current Members

Dominic Caputa, Zoe Vetter, and Emily Cobb