c-Myb Project
This is a pretty new, and relatively simple project that seeks to inhibit the c-myb protein which would stop a protein cascade involved in the proliferation of acute myeloid leukemia. The c-Myb protein serves as a transcription factor that then goes on to regulate the expression of other genes, and when there is a high level of the c-Myb protein it can help sustain the presence of the cancerous cells. The idea behind the project is to inhibit the active site of the c-myb protein between a lysine and glutamine residues using Celastrol as a scaffold for our drug candidates. We are working in conjunction with a clinical researcher at UChicago and will be reporting our results to them in time.
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