APOBEC3B Project
Apolipoprotein B mRNA editing enzyme catalytic-like 3B (APOBEC3B) is a member of APOBEC family of proteins. It is an internuclear protein and was initially thought to be developed as an antiviral. Its main function is as a cytidine deaminase or converting cytidine to uridine. The clinical implications of this protein are cancer that is more difficult to treat, and it is overexpressed in metastases. This protein has been found to be involved in the proliferation of breast, liver, and colon cancers. The goal of this project is potential lead molecule screening using qVina docking, AMBER molecular dynamics, statistical analysis, and de novo ligand growth to suggest potential inhibitors for future drug development.
Current Members:
Past Members:
Alyssa Tipler, Melissa Lee, Zachary Smith, Molly Huebner, Saul Armendariz Lobera, Richard Parks, Quin Blankenship, and Emmett Leddin.